A novel immune model predicts the prognosis of mantle cell lymphoma

Background Mantle Cell Lymphoma (MCL) is a subtype of B-cell lymphoma characterized by varied clinical manifestations. The immune status is associated with MCL’s development and outcome. This study aims to evaluate the prognostic value of peripheral cytokines and blood lymphocyte subsets in MCL patients. Methods This retrospective study analyzed patients’ clinical characteristics, treatment strategies, progression-free survival (PFS), and overall survival (OS). Immune cell levels and cytokines were evaluated via peripheral blood flow cytometry. Prognostic models incorporating immune characteristics were developed using XGBoost algorithms. Results The study involved 78 MCL patients with a median follow-up period of 40 months. The median PFS and median OS were 32 and 48 months. Univariate analysis linked poor PFS to factors including elevated β2-MG, Ann Arbor stage III-IV, low albumin levels (