Association of gastroesophageal reflux disease with the incidence of multiple cancers: a systematic review and meta-analysis

Objective: To investigate whether gastroesophageal reflux disease (GERD) is associated with an increased incidence of multiple cancers through a robust meta-analysis. Methods: We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science for observational studies published up to July 11, 2025. All statistical analyses were performed using R version 4.5.0. Results: A total of 17 studies were included. The pooled results indicated that GERD was significantly associated with an increased risk of lung cancer (OR = 1.33, 95% CI: 1.25-1.42), laryngeal cancer (OR = 1.75, 95% CI: 1.38-2.21), pancreatic cancer (OR = 1.30, 95% CI: 1.12-1.50), and esophageal cancer (OR = 1.70, 95% CI: 1.12-2.57). However, no significant association was found between GERD and colorectal cancer (OR = 1.04, 95% CI: 0.63-1.72). Conclusion: This meta-analysis suggests that GERD is associated with an increased incidence of multiple cancers. These findings will contribute to the clinical management of GERD patients, particularly in terms of cancer prevention and early screening.