Efficacy and safety of antibiotic regimens for Helicobacter pylori eradication: a systematic review and meta-analysis
Abstract
Background Helicobacter pylori infection, a global health concern, is treated with various antibiotic regimens, but rising resistance causes variable outcomes. This meta-analysis evaluated the efficacy and safety of different eradication regimens. Methods PubMed, Embase, and Web of Science were searched from inception to October 2025. Randomized and observational studies reporting eradication rates or adverse events were included. Pooled estimates were calculated using random-effects models with subgroup analyses and meta-regression. Results Fifty-seven studies (19,941 participants, 127 arms) were included. The pooled eradication rate was 83.0% (95% CI: 81.4%–84.5%; I²=87.3%). Egger's and Begg's tests indicated publication bias (both P
Fields of Study & Subjects
Helicobacter pylori-related gastroenterology studies
Clostridium difficile and Clostridium perfringens research
Steroid Chemistry and Biochemistry
Publication details
- Journal / source
- Frontiers in Medicine
- Publisher
- Frontiers Media SA
- Volume
- 13
- Pages
- 1780052–1780052
- Publication date
- 7 April 2026
- Language
- EN