Multi-site microbiota crosstalk in the postmenopausal: from dysbiosis mechanisms to precision interventions
Abstract
Persistent estrogen deficiency in postmenopause reshapes the gut-vaginal-urinary ecosystems, contributing to multisystem dysfunction through interconnected dysbiosis. Cross-niche microbial interactions amplify systemic risks: gut-derived toxins are linked to vascular inflammation, vaginal dysbiosis facilitates urinary pathogen colonization, and bile acid disruption impairs bone-immune homeostasis. This review synthesizes current mechanistic evidence illustrating how microbial networks propagate postmenopausal comorbidities. We propose the framework of "Postmenopausal Microbiota Network Medicine" which integrates microbial dynamics with host omics to transition from symptomatic management toward root-cause interception by strengthening microbial network resilience.
Fields of Study & Subjects
Gut microbiota and health
Reproductive tract infections research
Urinary Tract Infections Management
Publication details
- Journal / source
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Volume
- 17
- Pages
- 1702700–1702700
- Publication date
- 19 February 2026
- Language
- EN