Altered gut microbiota and serum metabolite profiles characterize postmenopausal bone loss: insights into the gut-bone axis

Frontiers in Microbiology 2026 Open access

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Authors: Zhiming Guan, Yanpin Liu, Junying Zhao, Longlong Jia, Yanyan Zhao, Hang Pan, Lijun Chen
DOI: 10.3389/fmicb.2026.1750495
Cited by: 1
References: 37

Abstract

Introduction Postmenopausal bone loss is a multifactorial condition influenced by hormonal changes, metabolic dysregulation, and gut microbiota alterations. Emerging evidence indicates the potential significance of the gut microbiota-bone link in maintaining bone homeostasis. The present study investigated the composition of the gut microbiota and serum metabolite signatures of postmenopausal women afflicted with bone loss, as well as the interrelationships between these factors, to explore the potential associations of the gut microbiota-bone link. Method In total, 105 postmenopausal women from Beijing were classified by DXA into a bone loss group (L1–L4 T -score

Fields of Study & Subjects

Gut microbiota and health Bone health and osteoporosis research Metabolomics and Mass Spectrometry Studies

Publication details

Journal / source
Frontiers in Microbiology
Publisher
Frontiers Media SA
Volume
17
Pages
1750495–1750495
Publication date
4 March 2026
Language
EN