Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies
Abstract
, a ubiquitous DNA betaherpesvirus, is capable of persistent infection and immunomodulation, particularly in immunocompromised and elderly hosts. Emerging evidence links HCMV to neurodegenerative diseases through its multifaceted immunomodulatory effects. This review summarizes key viral architectures and mechanisms, epidemiological trends, and experimental data supporting HCMV's role in cognitive decline. We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration.
Fields of Study & Subjects
Cytomegalovirus and herpesvirus research
Viral-associated cancers and disorders
Herpesvirus Infections and Treatments
Publication details
- Journal / source
- Frontiers in Aging Neuroscience
- Volume
- 17
- Pages
- 1757461–1757461
- Publication date
- 20 January 2026
- Language
- EN