Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies
Abstract
Neurodegenerative proteinopathies are characterized by impaired protein clearance and the accumulation of misfolded or aggregated proteins, ultimately leading to neuronal death. The two principal pathways responsible for protein degradation in cells are the ubiquitin proteasome system (UPS) and autophagy. Emerging evidence indicates that these pathways share regulatory components and engage in extensive crosstalk. In this review, we summarize the mechanisms of the UPS and autophagy, highlight their points of interaction, and discuss therapeutic opportunities to modulate both systems in parallel to enhance protein clearance in neurodegenerative disease.
Fields of Study & Subjects
Ubiquitin and proteasome pathways
Autophagy in Disease and Therapy
Protein Degradation and Inhibitors
Publication details
- Journal / source
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Volume
- 20
- Pages
- 1738415–1738415
- Publication date
- 18 February 2026
- Language
- EN