The correlation between auditory event-related potentials characteristics and cognitive function in insular glioma patients

Background: Auditory Event-Related Potentials (AERPs) characteristics, including mismatch negativity (MMN), P300, and event-related spectral perturbation (ERSP) are useful psychophysiological index that reflects cognitive functions, however, the relationship between AERPs characteristics and neuropsychological tests scores in insular glioma patients is unclear. Methods: Twenty-one insular glioma patients and 17 healthy control (HC) subjects were recruited. Age and education level were matched between the two groups. A correlation analysis was conducted between AERPs parametersr and neuropsychological test scores in patients with insular glioma. Results: The P300 peak latency at Fz electrodes under deviant stimuli showed significant negative correlations with execution function, fluency, calculation, and visual perception; and it showed significant positive correlations with Hamilton Depression Rating Scale (HDRS) scores, Hamilton Anxiety Rating Scale (HAMA) scores and Beck Depression Inventory (BDI) scores. The P300 peak latency at Cz electrodes under deviant stimuli showed significant negative correlations with fluency; and it showed significant positive correlations with HAMA scores and BDI scores. The MMN mean amplitude at Fz electrodes under novel stimuli showed significant positive correlations with fluency. Theta power at F4, F1, C1, AF3, and AF4 electrodes is positively correlated with naming function, while theta power at Fz electrode is negatively correlated with anxiety and action. Conclusion: The P300 peak latency and MMN mean amplitude are associated with multiple cognitive functions insular glioma patients, and event-related theta power mainly associated with naming function of insular glioma patients. Our results suggest that P300 latency, MMN amplitude and event-related theta power could be used as biological markers that indicate impaired neuropsychological functions in insular glioma patients.