Prognostic nomogram integrating inflammation and nutrition status for acute ischaemic stroke after mechanical thrombectomy

Background: The rate of ineffective recanalization after mechanical thrombectomy (MT) is approximately 50% in acute ischaemic stroke patients. Herein, we aim to investigate the correlation of inflammation and nutrition status with clinical outcome and construct a novel prognostic nomogram model to discriminate patients with high risk to facilitate early intervention. Methods: We conducted a prospective cohort study of a single-center patients with anterior circulation large-artery occlusion who underwent MT between October 2021 and October 2023. Demographic information and clinical characteristics were documented. According to the timing of admission, patients were divided into training and validation cohorts in a 7:3 ratio to developed and verified a prognostic nomogram for 90 day modified Rankin scale score (mRS) 0-3. Results: Totally, 569 patients were included in the final analysis. The 90 day mRS assessment identified 374 (65.7%) patients with mRS 0-3. Inflammation and nutritional indexes were independent predictors of 90-day mRS 0-3. The areas under the receiver operating curves of the developed nomogram model were 0.865 (95% CI: 0.826-0.905) and 0.861 (95% CI: 0.800-0.922) in the training and validation cohorts, respectively. Decision curve analysis indicated a good net benefit. Conclusion: Inflammation and nutritional status independently correlated with clinical outcome of anterior circulation large-artery occlusion stroke patients after MT.