A wearable deep brain stimulation system for behavioral studies in rodents

Introduction: Deep brain stimulation (DBS) has been demonstrated to improve motor function by modulating brain circuits. However, the precise mechanism of action remains unclear. Existing DBS devices often lack suitability for rodent models, which are essential for exploring these mechanisms. The objective of this study is to design a wearable DBS device that enables more effective rodent behavior research. Methods: We developed a stimulator specifically designed for rodent behavioral research. The device features several key advantages, including low weight (5 g excluding battery), compact size (30 mm × 38 mm), and extended battery life (≥300 hours). Additionally, it integrates low-power Bluetooth, allowing for real-time wireless adjustment of stimulation parameters, such as frequency (80-150 Hz), pulse width (40-340 μs), and amplitude (2.3-3 V). Results: The stimulating effect of this device has been verified in a model of mild Parkinson's disease (mild Parkinsonism) in rats, indicating that the device is effective in regulating the motor functions of rodents with Parkinson's disease-like conditions. Discussion: This wearable DBS device shows broad applicability in behavior-based studies and offers a valuable tool for investigating the mechanisms of various brain nuclei in rodent models. It holds significant potential for enhancing the exploration of DBS effects in clinical and experimental settings.