Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults

Frontiers in Nutrition 2026 Open access

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Authors: Yazhao Mei, Ziyuan Wang, Li Shen, Zhenlin Zhang, Hua Yue, Heng Zhang, Jiemei Gu, Weiwei HU, Shanshan Li, Chao Gao, Zhe Wei, Yang Xu
+3 more Jie Wang, Gao Gao, Chun Wang
DOI: 10.3389/fnut.2026.1782217
Cited by: 0
References: 24

Abstract

Objective Reference intervals (RIs) for vitamin B6 biomarkers remain underexplored in Chinese adults. We aimed to establish age- and sex-specific RIs of pyridoxal 5′-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (PA), and their ratios (PLP/PL, PLP/PA, and PAr), and to identify independent determinants of these markers. Methods Vitamin B6 metabolites were measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The distribution changes were illustrated by sex-stratified age percentile curves (P10/P50/P90). Robust 95% RIs (P2.5–P97.5) were obtained by sex and age (

Fields of Study & Subjects

Folate and B Vitamins Research Clinical Laboratory Practices and Quality Control Metabolism and Genetic Disorders

Publication details

Journal / source
Frontiers in Nutrition
Volume
13
Pages
1782217–1782217
Publication date
17 February 2026
Language
EN