Pre-diagnostic vitamin D deficiency and subsequent thyroid cancer risk: a propensity-matched cohort study

Frontiers in Nutrition 2026 Open access

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Authors: Kuo-Chuan Hung, Chia‐Li Kao, Ming Yew, Yi-Chen Lai, I-Wen Chen
DOI: 10.3389/fnut.2026.1817123
Cited by: 1
References: 27

Abstract

Background: Vitamin D deficiency (VDD) has been implicated as a potential risk factor for thyroid cancer; however, existing evidence is derived primarily from case-control or cross-sectional studies. This study aimed to examine the association between pre-diagnostic VDD and the risk of incident thyroid cancer over a 10-year follow-up period. Methods: This retrospective propensity score-matched cohort study used the TriNetX Global Collaborative Network. Adults aged ≥ 18 y with serum 25-hydroxyvitamin D [25(OH)D] measurements between 2010 and 2023 were classified as having VDD (

Fields of Study & Subjects

Vitamin D Research Studies Thyroid Cancer Diagnosis and Treatment Thyroid Disorders and Treatments

Publication details

Journal / source
Frontiers in Nutrition
Publisher
Frontiers Media SA
Volume
13
Pages
1817123–1817123
Publication date
21 April 2026
Language
EN