A real-world study on clinical features and prognosis of Chinese breast cancer patients with brain metastases

Frontiers in Oncology 2026 Open access

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Authors: Hongdan Chen, Xiao-wen Liao, Xiaogeng Chen, Yu-nan Su, Ding-Long Pan, Guo-zhong Chen, Min Wu, Shuang-Long Cai
DOI: 10.3389/fonc.2025.1497269
Cited by: 0
References: 33

Abstract

Background: This study aimed to analyze the clinical characteristics and prognosis of breast cancer (BC) patients with brain metastases (BM). Methods: We performed a retrospective analysis of breast cancer patients with brain metastases (BCBM) in a real-world setting. Results: In a cohort of 249 breast cancer brain metastasis (BCBM) patients (all female; median age 46 years), molecular subtypes were distributed as follows: luminal (38.95%), HER2-positive (32.93%), and triple-negative (28.11%). Distinct metastatic patterns were observed: luminal subtype correlated with bone metastases (55.73%, p

Fields of Study & Subjects

Brain Metastases and Treatment Lung Cancer Research Studies Lung Cancer Treatments and Mutations

Publication details

Journal / source
Frontiers in Oncology
Volume
15
Pages
1497269–1497269
Publication date
7 January 2026
Language
EN