Prognostic value of micro-RNA in ovarian cancer: a systematic review and meta-analysis

Background: Previous studies investigating the association between microRNAs (miRNAs) and ovarian cancer prognosis have yielded inconsistent results. This study aims to synthesize all available evidence through a systematic review and meta-analysis to provide a comprehensive assessment of the prognostic value of miRNAs in ovarian cancer. Methods: A systematic search was conducted in PubMed (from 1965), ISI Web of Science (from 1900), MEDLINE (from 1976), and Scopus (from 1968) through September 9, 2024. Studies published in English, examining the relationship between miRNAs and ovarian cancer prognosis, were included. miRNAs were categorized as upregulated or downregulated based on their expression levels in ovarian cancer tissues compared to normal tissues. The primary outcomes were the hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) of ovarian cancer patients. Results: A total of 51 studies involving 6916 ovarian cancer patients and 181 distinct miRNAs were included in the meta-analysis. Upregulated miRNAs were significantly associated with better OS in Chinese ovarian cancer patients compared to patients from other regions (HR 0.43 [95% CI: 0.20-0.65] vs. 1.01 [95% CI: 0.90-1.11], P