Treatment challenges in glioblastoma: a case report

This clinical case report aimed to show the survival timeline of a glioblastoma patient who underwent surgery and received adjuvant treatments in accordance with the Stupp protocol. Starting on the day of surgery, a liquid biopsy was employed to assess the dynamic alterations in cell-free DNA (cfDNA). Upon recurrence, reoperation was conducted, and repeated radiochemotherapy was applied. This clinical case is interesting due to the extended survival time, despite the extremely aggressive nature of the medical interventions. Liquid biopsies constitute a non-invasive method of characterising circulating tumour DNA (ctDNA) and evaluating genetic and epigenetic modifications, providing considerable potential for tumour diagnosis, prognosis, and management.