Functional pancreatic neuroendocrine tumors predominantly presenting with hypercalcemia: a case report

Frontiers in Oncology 2026 Open access

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Authors: Jieting Duan, Yanan Zhu, Yan Wang, Xiang Kui, Yingmei Tang
DOI: 10.3389/fonc.2025.1693096
Cited by: 0
References: 56

Abstract

Functional pancreatic neuroendocrine tumors (F-PNETs) that secrete parathyroid hormone-related protein (PTHrP) and cause hypercalcemia are extremely rare. This report details a 10-year course of a patient with pancreatic neuroendocrine tumor (PNET) and recurrent life-threatening hypercalcemia. Moreover, it comprehensively describes the evolution and management of hypercalcemia in this case, aiming to offer valuable insights for clinical diagnosis and treatment.

Fields of Study & Subjects

Neuroendocrine Tumor Research Advances Bone health and treatments Parathyroid Disorders and Treatments

Publication details

Journal / source
Frontiers in Oncology
Volume
15
Pages
1693096–1693096
Publication date
5 January 2026
Language
EN