Novel pencil-beam scanning proton lattice radiation therapy for the treatment of bulky liver cancer: dosimetric comparison with VMAT-lattice radiotherapy

Frontiers in Oncology 2026 Open access

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Authors: Yuting Li, Rachael M. Martin-Paulpeter, Christine Chung, Miguel A. Aguilar, Carlos A. Matias, A. Brito Delgado, Saurabh Sudhakaran Nair, Laurence E. Court, L Perles, Narayan Sahoo, Zhu Rx, Falk Poenisch
+7 more David B. Flint, Gabriel O. Sawakuchi, Sam Beddar, Eugene H. Koay, Jamie Baker, Ethan B. Ludmir, Joshua S. Niedzielski
DOI: 10.3389/fonc.2025.1731259
Cited by: 2
References: 45

Abstract

Background: Spatially fractionated radiotherapy (SFRT) delivered as lattice radiotherapy (LRT) creates high-dose 'vertex' subvolumes (VTVH) embedded within low-dose 'valley' regions (VTVL) to intensify intratumoral dose while minimizing radiation dose and toxicity to organs at risk (OARs). We developed a pencil-beam scanning (PBS) intensity modulated proton therapy (IMPT) LRT planning approach and dosimetrically compared it directly with contemporary photon-based volume modulated arc therapy (VMAT) LRT for liver cancer with bulky tumors. Methods: Twenty-one retrospective liver cases were replanned in RayStation to a single fraction of 20 Gy to VTVH with explicit VTVL sparing (mean dose

Fields of Study & Subjects

Radiation Therapy and Dosimetry Advanced Radiotherapy Techniques Boron Compounds in Chemistry

Publication details

Journal / source
Frontiers in Oncology
Publisher
Frontiers Media SA
Volume
15
Pages
1731259–1731259
Publication date
4 February 2026
Language
EN