Predictors of lymph node metastasis in resectable pancreatic neuroendocrine neoplasms: a single-center retrospective study

Background: Pancreatic neuroendocrine neoplasms (pNENs) present great heterogeneity in biological behavior, histological characteristics and clinical manifestations. Monocyte-to-lymphocyte ratio (MLR) is a noninvasive and easy-to-obtain indicator, that can reflect disease severity in multiple tumors. Lymph node metastasis (LNM) strongly affects the patient's surgical approach and prognosis. Predicting LNM before surgery has significance for the guidance of clinical treatment. We aimed to evaluate the predictive factors, including MLR associated with LNM of patients with resectable pNENs in our center. Methods: A total of 64 patients who underwent pNEN resection and lymph node dissection in our hospital from July 2014 until June 2023 were included in this study. Univariate and multivariate analyses were performed to identify predictive factors for LNM by analyzing clinical data, inflammatory markers, and pathological features. Results: Among the 64 patients, 15 (23.4%) were node positive. Univariate analysis revealed that vascular invasion, peripheral nerve invasion, bilirubin level, tumor grade, tumor size and MLR (p