Correlation analysis of clinical efficacy and prognosis of endoscopic submucosal dissection of early gastric cancer with peripheral blood indexes

Background: This study aimed to investigate the correlation between peripheral blood indicators and the clinical efficacy and prognosis of patients with early gastric cancer (EGC) undergoing endoscopic submucosal dissection (ESD). Methods: A single-center, retrospective cohort study was conducted on 120 EGC patients treated with ESD between January 2017 and August 2019. Patients were stratified into good (n=84) and poor (n=36) prognosis groups based on defined criteria. Univariate and multivariate logistic regression analyses were performed to identify factors influencing prognosis. The predictive performance of peripheral blood indicators was evaluated using receiver operating characteristic (ROC) curve analysis. Changes in biomarkers and patient-reported quality of life (assessed by QLQ-STO22) before and after ESD were compared, and their correlations were analyzed. Results: Univariate analysis revealed differences in Carbohydrate Antigen 19-9 (CA19-9), Carcinoembryonic Antigen (CEA), Neutrophil-to-lymphocyte ratio (NLR), Red blood cell distribution width (RDW), and Homocysteine (Hcy) levels between prognosis groups (all P