Multi-institutional MRI-based radiomic pilot study to measure the variations between scanner vendors and imaging sessions

Background: Multi-institutional clinical trials frequently use MRI imaging for critical decisions and guidance for medical treatments. Collecting and analyzing images produced by various MR vendors and models is quite difficult since image quality can be highly variable. No unifying quality control targeting protocol studies exists to ensure MRI images used in that study are comparable. This project will investigate variations between imaging sessions and between various scanners using radiomic parameters from prototype MRI QA phantom. Purpose: To develop a 3D radiomic phantom for quantifying radiomic feature consistency between MRI scanners across multi-institutions. Methods: , and scaffolding thickness of 1mm or 2mm. The egg-shaped objects are 5cm long with a 2cm or 4cm maximum diameter, filled with vitamin D3-capsules and olive-oil. It was scanned 10 times using T1- and T2-weighted sequences on Philips (1.5T Elekta Unity), GE (1.5T, Signa Artist), Siemens (1.5T MAGNETOM Sola), and Philips (1.5T Ingenia) across four institutions. TrueFISP and T2w sequences were used on ViewRay (0.35T MRIdian) scanners at two institutions. Per object, 107 radiomic features were extracted using the Pyradiomics extension in 3D Slicer. Coefficients of Variation (CV) of individual radiomic features were compared across 10 scans acquired on each scanner and used to compare radiomic feature consistency between objects and MRI scanners. Results: The radiomic feature consistency varied across objects with less reproducibility for the egg-shaped objects and more reproducibility for the grid objects, with slightly better reproducibility for T1w than T2w sequences. The GE scanner demonstrated better reproducibility than the other scanners. Both ViewRay scanners showed consistency for acquisitions with the TrueFISP sequence; the median CV of 107 radiomic features between objects was