Association of regional specificity of blood-brain barrier permeability with pathological subtypes in cerebral white matter of patients with non-brain metastatic lung cancer

Frontiers in Oncology 2026 Open access

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Authors: Haotian Wang, Jian Zeng, Zhengzhen Li, Yonglong Li, Yi Wang, Xiufu Zhang, Jun Zhou, Hongying Liu, Chunrong Wu, Ruipeng Liang
DOI: 10.3389/fonc.2026.1717244
Cited by: 1
References: 29

Abstract

Objective To investigate blood-brain barrier (BBB) permeability abnormalities in cerebral white matter regions of non-brain metastatic lung cancer (LC) patients and their association with histopathological subtypes. Methods 221 subjects (74 Healthy Controls [HC], 78 LC, 69 LC with Brain Metastasis [LCBM]) were enrolled. LC was subdivided into Adenocarcinoma (ADC), Squamous Cell Carcinoma (SCC), Small Cell Lung Cancer (SCLC). Dynamic Contrast-Enhanced MRI (DCE-MRI) assessed K trans , K ep , Ve, Vp in deep (frontal/parietal/temporal/occipital lobes) and periventricular (anterior/posterior horns) white matter. Non-parametric tests were used (p

Fields of Study & Subjects

MRI in cancer diagnosis Brain Metastases and Treatment Glioma Diagnosis and Treatment

Publication details

Journal / source
Frontiers in Oncology
Publisher
Frontiers Media SA
Volume
16
Pages
1717244–1717244
Publication date
23 February 2026
Language
EN