Clinical characteristics, treatment patterns, and survival in mantle cell lymphoma: a real-world cohort

Introduction: Mantle cell lymphoma is a rare, typically aggressive B-cell non-Hodgkin lymphoma that often presents at an advanced stage and carries substantial long-term mortality despite therapeutic advances. Multiple clinical, biological, and treatment-related factors may influence survival in these patients. Objective: To describe the clinical characteristics, treatment patterns, and overall survival of patients with mantle cell lymphoma at a high-complexity referral center in a middle-income country. Methods: This retrospective cohort included adult patients diagnosed and managed at a high-complexity referral center in Colombia between January 2016 and October 2025. Overall survival was the primary outcome. Survival estimates were obtained using Kaplan-Meier curves and compared with log-rank tests. Results: A total of 41 patients were included, with 43.9% aged