A comprehensive review of clear cell stromal tumor of the lung: integrating clinicopathology and molecular pathogenesis
Abstract
Clear cell stromal tumor (CCST) is a newly recognized mesenchymal neoplasm of the lung, with a recurrent YAP1::TFE3 gene fusion in most cases and characterized histologically by spindle, epithelioid cells, with variably clear to pale eosinophilic cytoplasm and prominent vascularity. Due to its rarity and the absence of specific immunohistochemical markers beyond TFE3, diagnosis remains challenging. Currently, only thirty cases have been documented. This narrative literature review synthesizes current advances to enhance understanding of this entity.
Fields of Study & Subjects
Medical Imaging and Pathology Studies
Sarcoma Diagnosis and Treatment
Hippo pathway signaling and YAP/TAZ
Publication details
- Journal / source
- Frontiers in Oncology
- Volume
- 16
- Pages
- 1760048–1760048
- Publication date
- 10 February 2026
- Language
- EN