Associations of three immune inflammatory markers with the risk of brain metastasis from lung cancer: a systematic review and meta-analysis

Objective This study sought to comprehensively evaluate the associations between three immune-inflammatory markers, namely neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), and the risk of brain metastasis from lung cancer (BMLC). Through a meta-analysis, this study was expected to offer evidence-based support for early clinical identification of high-risk patients. Methods Databases including PubMed, Cochrane, EMBASE, Web of Science, and Scopus were comprehensively searched. Relevant articles published up to November 2025 were retrieved. Cohort studies investigating the associations between the above markers and BMLC were included. Two researchers independently screened the articles, extracted data, and assessed study quality. Stata 15.0 was utilized to perform the meta-analysis. A random-effects or fixed-effects model was applied to pool the effect sizes. Subgroup analyses, meta-regression, sensitivity analyses, and publication bias assessment were conducted. Results Fourteen retrospective cohort studies were included, involving 3,643 participants with lung cancer. Pooled multivariate analyses revealed that elevated NLR served as an independent risk factor for BMLC (odds ratio [OR]=1.61, 95% confidence interval [CI]: 1.27–2.05, P Z