Paracetamol or ibuprofen? A pilot study comparing rescue therapy for PDA in preterm infants within the first month

Frontiers in Pediatrics 2026 Open access

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Authors: Arindam Mukherjee, Anupam Gupta, Catherine Fullwood, Ruth Gottstein
DOI: 10.3389/fped.2025.1717284
Cited by: 1
References: 18

Abstract

Aims and objectives To evaluate a study design aimed to assess the effectiveness and safety of IV paracetamol compared to IV ibuprofen for rescue treatment of clinically and hsPDA in preterm infants. Setting This pilot randomised controlled trial was conducted in the regional neonatal intensive care unit in Manchester, UK, between September 2021 and August 2023. Patients and methods The study recruited preterm infants (gestational age

Fields of Study & Subjects

Neonatal Respiratory Health Research Cardiovascular Conditions and Treatments Neonatal and fetal brain pathology

Publication details

Journal / source
Frontiers in Pediatrics
Publisher
Frontiers Media SA
Volume
13
Pages
1717284–1717284
Publication date
2 January 2026
Language
EN