A retrospective study on the treatment of superficial infantile hemangiomas of the head and neck using topical compresses with 0.5% timolol maleate eye drops

Frontiers in Pediatrics 2026 Open access

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Authors: Lu Yang, Feifan Chen, Kunpeng Li, Jiajun Chen, Wenying Angela Liu, YI JI, Meng Xia, Jing Xie, Ke Ding, Qiang Zeng, Fang Yao Stephen Hou
DOI: 10.3389/fped.2025.1734987
Cited by: 1
References: 48

Abstract

Introduction Infantile hemangiomas, the commonest benign vascular tumors of infancy, often cluster on the head and neck where early treatment can avert permanent disfigurement, prompting us to evaluate 0.5% timolol maleate wet compresses as a non-invasive alternative to oral propranolol. Methods We conducted a study of 359 consecutive infants treated at Sichuan Provincial People's Hospital between December 2018 and January 2024. Baseline demographics, lesion site and size, age at initial treatment, treatment duration, and follow-up period were recorded. Treatment outcomes were graded as excellent (complete regression), good (≥50% shrinkage), fair (

Fields of Study & Subjects

Vascular Malformations and Hemangiomas Teratomas and Epidermoid Cysts Reconstructive Facial Surgery Techniques

Publication details

Journal / source
Frontiers in Pediatrics
Publisher
Frontiers Media SA
Volume
13
Pages
1734987–1734987
Publication date
19 January 2026
Language
EN