Association of serum methylglyoxal with endothelial dysfunction in patients with type 2 diabetes

Frontiers in Pharmacology 2026 Open access

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Authors: Shanshan Yu, Xinyan Jin, Yuanying Xu, Zhao Liu, Jun Lü, Jie Gao, Wenjun Sha, Tao Lei
DOI: 10.3389/fphar.2026.1773149
Cited by: 0
References: 28

Abstract

Aims: To explore the correlation between serum Methylglyoxal (MGO) and endothelial dysfunction in patients with type 2 diabetes mellitus, and to evaluate the clinical value of MGO in the development of diabetes mellitus and its complications. Methods: In this cross-sectional study, we enrolled 250 patients diagnosed with T2MD. Based on flow-mediated dilation (FMD) measurements, the patients were categorized into normal endothelial function group (FMD ≥6.4%, n = 61) and endothelial dysfunction group (FMD

Fields of Study & Subjects

Advanced Glycation End Products research Nitric Oxide and Endothelin Effects Cardiovascular Health and Disease Prevention

Publication details

Journal / source
Frontiers in Pharmacology
Volume
17
Pages
1773149–1773149
Publication date
4 February 2026
Language
EN