Patient perspectives on epidermal growth factor receptor inhibitor-induced skin toxicities: a qualitative study

Objective: This study systematically explored the experience and supportive care needs of patients with cancer developing skin toxicity following Epidermal Growth Factor Receptor Inhibitor (EGFRI) treatment. Methods: A descriptive qualitative study was conducted. A total of 9 patients with cancer recruited from a single tertiary hospital in Zhejiang Province between July and August 2024 participated in semi-structured interviews. Data were analyzed using Colaizzi's seven-step method to systematically derive themes related to patients' experiences and care needs. Results: This study extracted a total of five themes and thirteen sub-themes, which included adverse physiological experiences, coexistence of negative and positive emotional experiences, impacts on daily life, diverse coping styles, and desire for medical support and help. Conclusion: Clinical staff should prioritize attention to the physical and psychological distress experienced by patients with cancer with EGFRI-induced skin toxicities. Implementing enhanced symptom evaluation and management, providing tailored psychological support, and offering professional guidance can help patients effectively cope with their symptoms and foster their self-growth.