Knowledge, attitudes, and practices regarding osteoporosis among hormone receptor-positive breast cancer patients: a cross-sectional study

Objective To investigate the knowledge, attitudes, and practices (KAP) concerning osteoporosis among hormone receptor-positive (HR+) breast cancer patients. Methods A cross-sectional study was conducted from November, 2023, to March, 2024 among HR+ breast cancer patients to assess their KAP regarding osteoporosis. Structural equation modeling (SEM) was employed to assess the relationships among the KAP dimensions. Results A total of 758 HR+ breast cancer patients were invited, 610 completed the questionnaire (response/completion rate: 80.5%), and 491 questionnaires were retained for the final analysis after prespecified data cleaning (analytic inclusion rate: 64.8%). HR+ breast cancer patients had insufficient knowledge (mean 9.69, SD 5.93), moderate attitudes (mean 29.50, SD 4.55), and moderate practices (mean 35.85, SD 4.75). SEM showed that knowledge directly influenced attitudes (β = 0.509, P < 0.001), while both knowledge (β = 0.585, P < 0.001) and attitudes (β = 0.402, P < 0.001) had direct effects on practices. Conclusions HR+ breast cancer patients exhibit insufficient knowledge, positive attitudes, and suboptimal practices regarding osteoporosis.