Microplastics in neonates: an overlooked cost of parenteral nutrition

Introduction: Microplastics (MPs) are emerging contaminants that raise concerns due to their potential health effects on vulnerable neonates who may be exposed to medical devices. Methods: This prospective study investigated the presence of MPs in neonatal blood in relation to parenteral nutrition (PN) duration. A total of 12 neonates were categorized into long-term (>14 days), short-term (3-7 days), and non-exposed control groups. MPs were analyzed using confocal micro-Raman spectroscopy. Results: < 0.05), demonstrating a dose-response relationship with PN duration. Notably, larger MPs (>60 μm) were found exclusively in the long-term group. Discussion: These preliminary findings, derived from a small sample cohort, suggest that the PN system may serve as a potential iatrogenic source of MPs for neonates. Clinical trial registration: NCT07326761.