Research progress on TWEAK/Fn14 signaling in chronic wound healing
Abstract
Chronic wounds are characterized by persistent inflammation and altered microenvironments, exhibiting prolonged healing and difficult repair, presenting significant therapeutic challenges. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), by binding to its receptor fibroblast growth factor-inducible 14 (Fn14), participates in cellular regulation, wound repair, and inflammatory response processes, playing an important role in chronic wound healing. This review summarizes the pathophysiological mechanisms of chronic wounds, the mechanisms of action of the TWEAK/Fn14 signaling pathway in chronic wound healing, and the latest research progress on its potential as a therapeutic target.
Fields of Study & Subjects
NF-κB Signaling Pathways
FOXO transcription factor regulation
Melanoma and MAPK Pathways
Publication details
- Journal / source
- Frontiers in Surgery
- Publisher
- Frontiers Media SA
- Volume
- 13
- Pages
- 1769996–1769996
- Publication date
- 29 April 2026
- Language
- EN