One Network–One Nation–One Health India’s Strategic Blueprint for Resilient, Cross-Sectoral Health Systems

The escalating threats of zoonotic diseases, antimicrobial resistance (AMR), climate change, and environmental degradation have intensified the need for a unified health approach. One Health—integrating human, animal, and environmental health—is critical for national and global health security. India, with its high population density, biodiversity, and socio-ecological complexity, stands poised to lead in operationalizing this integrated vision. This review analyzes India’s evolving One Health ecosystem, focusing on policy development, inter-ministerial collaborations, surveillance systems, grassroots implementation, and education. Institutions like the National Centre for Disease Control (NCDC), Indian Council of Medical Research (ICMR), and Department of Biotechnology (DBT) are discussed. We propose a strategic blueprint built on integrated surveillance (One Network), cross-sectoral governance (One Nation), and field-level implementation (One Health). Highlighting successful case studies and India’s role in global platforms, the article presents a roadmap to bridge fragmented efforts into a resilient, community-driven national mission to protect human, animal, and environmental health.