Vancomycin Dosing Regimen to Obtain the Target Area Under the Concentration–Time Curve, Which Provides an Early Treatment Response for Patients on Haemodialysis

Antibiotics 2026 Open access

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Authors: Minori Kambe, Takashi Ueda, Kazutaka Oda, Kazuhiro Sugiyama, Kazuhiko Nakajima, Naruhito Otani, Motoi UCHINO, Yuki Horio, Ryuichi Kuwahara, Masanobu Toyama, Makoto Tomita, Atsuki Ide
+3 more Mayuko Ao, Yasuhiro Nozaki, Yoshio Takesue
DOI: 10.3390/antibiotics15010047
Cited by: 1
References: 30

Abstract

Objectives: This study aimed to clarify the area under the curve (AUC) for obtaining better clinical outcomes and to demonstrate vancomycin dosing for achieving the AUC in haemodialysis (HD). Methods: The vancomycin concentration was measured before the second HD. The AUC24–48h after the initial HD was assessed to evaluate its correlation with an early clinical response and to determine the dosing regimen, assuming an inter-dialysis interval of 48 h, even if the interval was 72 h. Results: An AUC/MIC ≥ 400 was an independent factor for an early response in treating MRSA infections and infections caused by methicillin-resistant Gram-positive organisms. An AUC of 600–700 μg·h/mL did not increase the incidence of adverse effects compared with that of

Fields of Study & Subjects

Antimicrobial Resistance in Staphylococcus Antibiotics Pharmacokinetics and Efficacy Clostridium difficile and Clostridium perfringens research

Publication details

Journal / source
Antibiotics
Publisher
MDPI AG
Volume
15
Issue
1
Pages
47–47
Publication date
3 January 2026
Language
EN