Angiotensin-Converting Enzyme (ACE) Inhibitors and Statins Mitigate Negative Cardiovascular and Pulmonary Effects of Particulate Matter in a Mouse Exposure Model

Antioxidants 2026 Open access

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Authors: Tristan Junglas, Andreas Daiber, Ivana Kuntić, Arijan Valar, Jiayin Zheng, Matthias Walter Oelze, Lea Strohm, Henning Ubbens, Omar Hahad, María Teresa Bayo Jiménez, Thomas F. Münzel, Marin Kuntić
DOI: 10.3390/antiox15010106
Cited by: 0
References: 93

Abstract

Particulate matter (PM) is a significant contributor to air pollution-associated negative health effects, and cardiovascular disease patients are more susceptible to air pollution-mediated damage of the heart and vessels. The present study investigated the protective effects against PM-induced cardiovascular damage by classic cardiovascular drugs, as used for the standard therapy of cardiovascular disease patients. Male C57BL/6J mice were exposed to ambient PM2.5 (

Fields of Study & Subjects

Air Quality and Health Impacts Nitric Oxide and Endothelin Effects Atherosclerosis and Cardiovascular Diseases

Publication details

Journal / source
Antioxidants
Volume
15
Issue
1
Pages
106–106
Publication date
13 January 2026
Language
EN