Oxidative Stress and NRF2-Mediated Redox Regulation in Incomplete Systemic Lupus Erythematosus and Systemic Lupus Erythematosus

Antioxidants 2026 Open access

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Authors: Lu Liu, Svenja Henning, Harry van Goor, Hendrika Bootsma, B Doornbos-van der Meer, Johanna Westra, Karina de Leeuw
DOI: 10.3390/antiox15080995
Cited by: 0
References: 54

Abstract

Highlights● Increased oxidative stress and decreased antioxidative capacity are present in systemic lupus erythematosus (SLE) patients● Reduced anti-oxidant gene expression in peripheral blood mononuclear cells is observed in both iSLE and SLE patients compared to healthy controls● Treatment with nuclear factor erythroid-derived 2-like 2 agonists upregulates expression of antioxidative genes in peripheral blood mononuclear cells and HaCaT keratinocytes● Oxidative stress pathways in SLE patients can potentially be modulated, which may be beneficial in early disease stages

Fields of Study & Subjects

Systemic Lupus Erythematosus Research Genomics phytochemicals and oxidative stress Atherosclerosis and Cardiovascular Diseases

Publication details

Journal / source
Antioxidants
Volume
15
Issue
8
Pages
995–995
Publication date
11 August 2026
Language
EN