Assessment of Implant Stability Using ISQ, Periotest, and CBCT in a Split-Mouth Pilot Study

This split-mouth pilot study evaluated implant stability using resonance frequency analysis (ISQ), Periotest measurements (PTV), and CBCT imaging as a supportive descriptive modality. Twenty patients requiring implant placement in the anterior maxilla underwent bilateral augmentation with deproteinized bovine bone mineral, with an adjunctive polynucleotide–hyaluronic acid complex applied at one site and the contralateral site serving as control. Implants were placed after a standardized 6-month healing period. Implant stability was recorded at placement and during follow-up. Test sites showed slightly higher ISQ values and more negative PTV values at placement, followed by progressive stabilization in both groups during healing. Parallel trends of increasing ISQ and decreasing PTV values were observed over time. CBCT was used exclusively for intra-patient comparative and morphologic assessment. Within the limitations of this pilot design, implant stability measurements should be interpreted as functional indicators of the implant–bone complex during early healing. The combined use of ISQ and Periotest measurements may support longitudinal monitoring of implant stability in routine clinical practice. Further studies with larger cohorts and extended follow-up are warranted.