Malaria in the 21st Century: Global Disease Burden, Epidemiological Insights, and Strategic Control Approaches

Malaria remains a major public health issue worldwide and a repeated cause of illness and death in tropical and subtropical areas. It is caused by protozoan parasites of the genus Plasmodium and transmitted through bites of infected female Anopheles mosquitoes, but it can also be transmitted via blood transfusions, organ transplants, and congenitally from mother to child. Despite decades of intervention efforts, millions of new cases and hundreds of thousands of deaths still occur each year, primarily in low- and middle-income countries. This review summarizes current epidemiological data on the global burden of malaria, mainly from the World Health Organization's (WHO) World Malaria Report 2024 and Global Burden of Disease estimates. It brings together the latest evidence on worldwide malaria epidemiology, regional trends, determinants, and control strategies, with a particular focus on socio-economic factors, intervention methods, and emerging challenges such as drug resistance, climate change, and limited funding. Disease prevention and management require global, multifactorial approaches that are tailored to the local environment. Strengthening health education with locally relevant knowledge is important to improving outcomes in primary health prevention, secondary health prevention, and tertiary health prevention. The review concludes with a discussion of policy priorities needed in the future to meet the WHO Global Technical Strategy goals for malaria elimination by 2030.