Advances in Cytokines and Inflammatory Mechanisms in the Pathogenesis of Interstitial Cystitis/Bladder Pain Syndrome
Abstract
Bladder discomfort, urgency, and frequency of urination are the hallmarks of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic illness. Although the precise etiology remains unclear, numerous clinical investigations have established inflammation as a pivotal factor in its pathogenesis, encompassing uroepithelial damage, mast cell activation, and neuroinflammatory responses. This review delineates the pathological features and classification of IC/BPS, emphasizing the contribution of inflammatory mechanisms and the involvement of cytokines as key mediators in disease progression. The insights presented aim to guide the advancement of innovative treatment approaches.
Fields of Study & Subjects
Urinary Bladder and Prostate Research
Urinary Tract Infections Management
Sexual function and dysfunction studies
Publication details
- Journal / source
- Biomolecules
- Publisher
- MDPI AG
- Volume
- 16
- Issue
- 1
- Pages
- 138–138
- Publication date
- 13 January 2026
- Language
- EN