NLRP3 Inflammasome Role and NLRP3 Inhibitors in Sensorineural Hearing Loss

Biomolecules 2026 Open access

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Authors: Mireia Toledano-Pinedo, José Marco-Contelles, Alexey V. Dobrydnev
DOI: 10.3390/biom16020186
Cited by: 1
References: 33

Abstract

Herein, we will review the function of the NLRP3 inflammasome in hearing loss (HL), summarize the most significant experimental results described in recent years, describe the biological mechanisms involved in the role of NLRP3 inflammasome in HL, and highlight some of the most promising small NLRP3 inhibitors for its clinical therapy, showing excellent pharmacological effects and good pharmacodynamic/pharmacokinetic profiles.

Fields of Study & Subjects

Inflammasome and immune disorders Hearing Cochlea Tinnitus Genetics Vestibular and auditory disorders

Publication details

Journal / source
Biomolecules
Publisher
MDPI AG
Volume
16
Issue
2
Pages
186–186
Publication date
26 January 2026
Language
EN