Intranasal Resveratrol Plus Carboxymethyl-β-Glucan: A Promising Option in Clinical Practice

Resveratrol is a polyphenol with numerous beneficial properties, acting as a phytoalexin. Plants produce resveratrol in response to various types of stress, such as infections and external damage. Resveratrol is a natural medicine thanks to its antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, and antiallergic properties. However, resveratrol has poor oral bioavailability. To overcome this drawback, a topical nasal formulation has been developed, characterized by the fixed combination of carboxymethyl-β-glucan (CMBG) with trans-resveratrol. This innovative molecule has been the subject of in-depth preclinical studies to demonstrate its stability and solubility. Subsequently, several controlled clinical studies have shown that this formulation is effective and safe in patients with respiratory infections, allergic rhinitis, and nasal surgery. Therefore, taken together, these findings suggest that intranasal resveratrol-CMBG might be a promising option for the management of upper airway diseases.