Modulation and Reprogramming of Adipose Tissue Macrophages in Obesity

Biomolecules 2026 Open access

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Authors: Yan Liu, Xiaoying Huang, Linfeng Sang, Yang Zhang, Jiajie Cao, Qin Kong
DOI: 10.3390/biom16020339
Cited by: 2
References: 205

Abstract

Chronic inflammation associated with obesity drives metabolic dysfunctions and induces immune cell maintenance. Adipose tissue macrophages (ATMs), the predominant immune population within adipose depots, exhibit substantial heterogeneity and serve as central pathological mediators in obesity-induced adipose inflammation and metabolic dysregulation. In this review, we highlight the reprogramming of ATMs' metabolic pathways, including glucose and lipid homeostasis associated with obesity, with a focus on chronic metabolic inflammation. Additionally, we discuss underlying mechanisms supporting ATMs remodeling in obesity, including transcriptional control and epigenetic regulation.

Fields of Study & Subjects

Adipokines Inflammation and Metabolic Diseases Adipose Tissue and Metabolism Immune cells in cancer

Publication details

Journal / source
Biomolecules
Publisher
MDPI AG
Volume
16
Issue
2
Pages
339–339
Publication date
23 February 2026
Language
EN