The Mechanism and Regulation of Disulfidptosis and Its Role in Disease
Abstract
Disulfidptosis is a recently identified form of regulatory cell death (RCD), Which has emerged as a research hotspot due to its distinctive feature of accumulating protein disulfide bonds, setting it apart from other RCD mechanisms. This discovery may offer new therapeutic strategies for cancer and various chronic diseases. This review aims to summarize the molecular mechanisms, inhibitors, regulatory networks, distinctions and connections between disulfidptosis and other regulatory death pathways, and the application of disulfidptosis in tumors and other chronic diseases. It also identifies unresolved issues and provides an outlook on future prospects.
Fields of Study & Subjects
Endoplasmic Reticulum Stress and Disease
Ferroptosis and cancer prognosis
Redox biology and oxidative stress
Publication details
- Journal / source
- Biomedicines
- Publisher
- MDPI AG
- Volume
- 14
- Issue
- 1
- Pages
- 228–228
- Publication date
- 21 January 2026
- Language
- EN