Effect of Autologous Bioactive Concentrated Growth Factor and Residual Dental Pulp on Dentin–Pulp Complex Regeneration

Background/Objectives: This study aimed to evaluate the regenerative potential of autologous concentrated growth factor (CGF) combined with residual pulp tissue in immature dog teeth using a histological and histomorphometric analysis. Materials and Methods: Thirty immature anterior and premolar teeth, harvested from four dogs, were randomly assigned to three groups (n = 10 each): group I (negative control, untreated teeth), group II (positive control, complete pulp removal with blood clot in the canal), and group III (experimental, partial pulp removal with 1–4 mm residual pulp and placement of autologous CGF). After 1 and 3 months, animals were euthanized, and samples were processed for histological and histomorphometric assessments. Results: The CGF-treated group exhibited newly formed tissue with morphological characteristics comparable to the negative control group after partial pulp removal. Conclusions: The combination of CGF with 1–4 mm of residual pulp was associated with enhanced tissue organization, representing a promising approach for dentin–pulp complex (DPC) regeneration within this experimental context.