Advances in the Synthesis of Heterocyclic Compounds and Their Applications

This Special Issue, entitled Advances in the Synthesis of Heterocyclic Compounds and Their Applications, aims to expand our scientific knowledge about the current world by exploring the differences between at least two of their lively interfaces: human life and the environment.From this perspective, our previous traditional strategies, heteroring synthesis and substituent modification (including their combination), require an update to their meaning in terms of two actual conceptual approaches, namely covalent vs. non-covalent, with reference to all types of heteromolecules, from the smallest to (supramolecular) 2(3)D nano-architectures (dendrimers, MOFs, COFs, etc.) without neglecting the still exotic molecular machines.Subject to all evolutionary facets of heterocyclic chemistry, the perpetual developments reimagined within the current organic heterosynthesis (strategies, methodologies, reaction mechanisms, reagents, catalysts, chemical and instrumental auxiliaries) nevertheless obey two crucial common denominators, selectivity vs. specificity (these terms being, equally, preceded by typical prefixes, either chemo-, regio-, or stereo-), as mandatory criteriums.