Immune-Centered Cross-Talk Between Cancer Cells and the Tumor Microenvironment—Implications for Therapy
Abstract
The tumor microenvironment (TME), composed of various immune and non-immune cells, as well as cancer stem cells, plays a critical role not only in promoting cancer cell proliferation and metastasis but also in modulating therapeutic response. A wide range of therapeutic strategies targeting the TME are currently employed in cancer treatment, including standard chemotherapy, radiotherapy, immunotherapy, anti-angiogenic therapies, agents targeting cancer-associated fibroblasts (CAFs), oncolytic viruses (OVs), cold atmospheric plasma therapy, and nanovaccines. This review provides a comprehensive overview of the influence of the TME on cancer sensitivity to these therapies across all types of solid tumors.
Fields of Study & Subjects
Cancer Research and Treatments
Cancer Cells and Metastasis
Nanoplatforms for cancer theranostics
Publication details
- Journal / source
- Cancers
- Publisher
- MDPI AG
- Volume
- 18
- Issue
- 3
- Pages
- 344–344
- Publication date
- 23 January 2026
- Language
- EN