Advancing the Study of Glioblastoma Through 3D Tumor Models

Cancers 2026 Open access

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Authors: Karen Salmeron-Moreno, Josephine Buclez, Chris Donghyun Kim, Karthik Papisetty, Thomas D. McCaffery, Fadi Jacob, Rommi Kashlan, Hithardhi Duggireddy, Karthik Valiveti, Justin Maldonado, Gustavo Pradilla, Tomás Garzón-Muvdi
DOI: 10.3390/cancers18040668
Cited by: 2
References: 144

Abstract

Glioblastoma (GBM), the most aggressive primary brain malignancy, remains a challenge to experimentally model. Accurately modeling the intra- and intertumoral heterogeneity of GBMs is essential for enhancing the predictive power of preclinical models and improving the effectiveness of current therapies. This review highlights recent advances in 3D tumor modeling, which accurately replicate the structural, cellular, and biochemical complexity of GBMs. We examine their translational potential and discuss current barriers to clinical translation.

Fields of Study & Subjects

Glioma Diagnosis and Treatment Mathematical Biology Tumor Growth Cell Image Analysis Techniques

Publication details

Journal / source
Cancers
Publisher
MDPI AG
Volume
18
Issue
4
Pages
668–668
Publication date
18 February 2026
Language
EN