Part 1: The Role of Thyroglobulin Antibodies in Thyroid Cancer Development and Aggressiveness

Cancers 2026 Open access

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Authors: Rodis D. Paparodis, Evangelos Karvounis, George Simeakis, Ioannis Androulakis, Dimitrios P. Askitis, Sarantis Livadas, Andreas A Rizoulis, Vasileios Papanikos, NICHOLAS S. MASTRONIKOLIS, Dimitra Zianni, Charalampos Massouras, Ilias Perogamvros
+6 more Anastasios Boniakos, Nicholas Angelopoulos, Dimitra Bantouna, Aikaterini Kapezanou, Ourania Aporelli, Juan Carlos Jaume
DOI: 10.3390/cancers18050790
Cited by: 0

Abstract

Introduction: Thyroglobulin antibodies (Tg-Abs) are often thought to be associated with thyroid autoimmunity, and as such, a link with thyroid cancer has been found in some, but not all, studies. Tg-Abs are also found in non-autoimmune thyroid-follicular destruction. Given these contradictory results, we designed the present study. Methods: We reviewed data from patients undergoing thyroidectomy for different indications in multiple centers across Greece and the US over 10 years. We compared the incidence of thyroid cancer and its features of tumor aggressiveness among patients with positive (≥30 IU/mL) and negative (

Fields of Study & Subjects

Thyroid Cancer Diagnosis and Treatment Thyroid and Parathyroid Surgery Thyroid Disorders and Treatments

Publication details

Journal / source
Cancers
Volume
18
Issue
5
Pages
790–790
Publication date
28 February 2026
Language
EN