The Obesity Paradox in Hepatocellular Carcinoma: Insights from Continuous and Interaction-Based Analyses of Body Mass Index After Hepatic Resection

Cancers 2026 Open access

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Authors: B. Chul Lee, Ho-Seong Han, Yoo-Seok Yoon, Jai Young Cho, Hae Won Lee, Yeshong PARK, H. W. Joo, Seung Yeon Lim
DOI: 10.3390/cancers18071143
Cited by: 1
References: 28

Abstract

Background/Objectives: The prognostic significance of body mass index (BMI) in hepatocellular carcinoma (HCC) remains controversial, and whether the obesity paradox may reflect tumor biology or host-related factors is unclear. This study evaluated the association between BMI and survival after curative hepatic resection using continuous and interaction-based analyses. Methods: We retrospectively analyzed 1349 patients who underwent curative hepatic resection for HCC between 2004 and 2021. BMI was assessed both categorically (low (

Fields of Study & Subjects

Hepatocellular Carcinoma Treatment and Prognosis Liver Disease Diagnosis and Treatment Organ Transplantation Techniques and Outcomes

Publication details

Journal / source
Cancers
Publisher
MDPI AG
Volume
18
Issue
7
Pages
1143–1143
Publication date
2 April 2026
Language
EN