Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review

Cancers 2026 Open access

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Authors: Meghana Maddula, Jordan E. Cohen, Dulitha Kumarasinghe, Mandy L. Ballinger, Jaqueline L. E. Tearle, Kylie R. James, Adnan Nagrial, Megan Barnet, Subotheni Thavaneswaran
DOI: 10.3390/cancers18101515
Cited by: 1
References: 107

Abstract

Background: The incidence of early-onset colorectal cancer (EOCRC) is rising globally, yet its underlying risk factors remain incompletely understood, particularly in cases without recognised hereditary syndromes. Objectives: To update and synthesise the current body of evidence on modifiable and non-modifiable risk factors for sporadic early-onset colorectal cancer. Methods: A systematic review of peer-reviewed articles published in English reporting original observational research examining risk factors for sporadic early-onset colorectal cancer (

Fields of Study & Subjects

Colorectal Cancer Screening and Detection Genetic factors in colorectal cancer Cancer Risks and Factors

Publication details

Journal / source
Cancers
Publisher
MDPI AG
Volume
18
Issue
10
Pages
1515–1515
Publication date
8 May 2026
Language
EN