Transition-Metal-Free and HI-Catalyzed Synthesis of 2,3-Dihydrobenzothiazin-4-one Derivatives
Abstract
A transition-metal-free strategy for the synthesis of 2,3-dihydrobenzothiazin-4-one derivatives has been established. Using HI as the catalyst, various 2-substituted, N-substituted compounds and variations on the benzamide ring were synthesized in excellent yields via the reaction between 2-mercaptobenzamides and aldehydes. In addition, an easy experimental procedure, broad substrate scope, and excellent functional group tolerance demonstrate that this catalytic protocol provides a valuable complementary approach for accessing 2,3-dihydrobenzothiazin-4-one derivatives.
Fields of Study & Subjects
Phenothiazines and Benzothiazines Synthesis and Activities
Quinazolinone synthesis and applications
Synthesis and Catalytic Reactions
Publication details
- Journal / source
- Catalysts
- Publisher
- MDPI AG
- Volume
- 16
- Issue
- 1
- Pages
- 68–68
- Publication date
- 7 January 2026
- Language
- EN